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In preparing these guidelines the authors have considered overall cost-effectiveness of recommended interventions as well as clinical efficacy data but formal health economic assessments have not been carried out. The use of these guidelines to assist management of individual patients should be combined with appropriate professional training. All drug doses should be checked at reference sources, such as the British National Formulary (BNF), Palliative Care Formulary (PCF) or similar. The authors, BCSH or publishers http://en.wikipedia.org/wiki/Methisazone cannot take legal responsibility for individual patient management. Anaemia (haemoglobin concentration http://www.selleckchem.com/products/bay-57-1293.html chemotherapy. Other causes, such as haematinic deficiency or bleeding, should be excluded. Fatigue is also reported by many patients and may be caused by both physical and psychological factors related to the disease and its treatment but anaemia has been shown to be an important contributory factor (Cella et?al, 2004). A European wide survey in patients with myeloma suggested that prevalence of anaemia during chemotherapy is around 85% (Birgegard et?al, 2006). Anaemia may be managed by blood transfusion or treatment with erythropoiesis-stimulating agents (ESAs). Blood transfusion may be very helpful in the short-term correction of moderate to severe anaemia in a symptomatic individual. Minimally or asymptomatic individuals http://www.selleckchem.com/products/Roscovitine.html with mild or moderate anaemia (due to their disease) may be observed and some will become less anaemic as the myeloma is controlled with chemotherapy. ESA treatment is recommended for anaemic patients with myeloma with associated renal impairment (Locatelli et?al, 2004). ESA doses of