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Parametric multiphase hazard analysis identified two distinct http://www.selleck.cn/products/bgj398-nvp-bgj398.html phases of risk (Figure 1A, lower plot). The first phase was dominant during the first 2 years posttransplantation and fit a shaping function in which there is a rapidly increasing hazard early posttransplantation, peaking by 5.6 months posttransplantation, and then rapidly decreasing into a second phase (2�C18 years posttransplantation) in which the hazard gradually increases over time (Figure 1A). This is consistent with the observed gradual decline in freedom from PTLD during the same period (Figure 1A, top). To quantify the risk and to understand its relationship to time, we performed an analysis of time-varying risk for freedom from PTLD. Figure 1B shows the proportion free from PTLD versus time posttransplantation stratified by the categories infants, children and adolescents. Actuarial freedom from PTLD was significantly http://www.selleckchem.com/products/Bortezomib.html different between these three groups (p = 0.006). The proportion free of PTLD appeared to be lowest in children (1 to http://www.selleckchem.com/products/gsk1120212-jtp-74057.html in children at 5.5 years of age at transplant versus those transplanted at ages 6 months (infants) or 14 years (adolescents). This is consistent with the multivariable analysis showing the age range 1�C9 years (children) is a risk factor for PTLD in comparison to older and younger ages (Table 1). Notably, the relative differences in hazard for PTLD in the early phase did not correspond with the relative relationships in the late phase, indicating that the risk factors for PTLD change as a function of both age at the time of transplant and time posttransplantation. This is readily apparent in Figure 2, which shows the hazard for PTLD as a function of age at the time of transplant at different times posttransplantation. At 1 year posttransplantation, the hazard for PTLD is substantially higher among children versus infants and adolescents. This difference as a function of age at transplant is reduced at later times posttransplantation.