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Negative and positive predict values were 83.7% and 75%, respectively. The accuracy of the model was 82%. Five http://www.selleck.cn/products/pd-1-pd-l1-inhibitor-2.html patients developed CMV disease (Table 4). However, this scarce number prevented us from performing a multivariate analysis. In order to determine whether ��CMV-serostatus�� and ��pretransplant QF-CMV�� were independent variables or, on the contrary, were associated, we performed a test of independence using a chi-squared test. The test result (p http://www.selleckchem.com/products/MDV3100.html 1.5�C32.0) and the 4 recipients with CMV replication showed a median of 5.8 IU/mL (interquartile range 3.8�C13.4). To determine whether R(+)QF-CMVNR and R(+)QF-CMVR also behaved differently at the onset of posttransplant CMV replication and the kinetics of CMV replication, we analyzed parameters such as posttransplant day of CMV replication, peak CMV load and duration of CMV replication episodes. Since in lung recipients CMV replicates after discontinuing antiviral prophylaxis, Table 5 only shows the values for kidney transplant recipients. In R(+)QF-CMVNR recipients, the virus replicated earlier than in R(+)QF-CMVR patients. In addition, the peak CMV load was higher and the duration of CMV replication was longer than in R(+)QF-CMVR patients. Two of the R(+)QF-CMVNR recipients developed CMV disease, while the three R(+)QF-CMVR http://www.selleckchem.com/products/gsk1120212-jtp-74057.html recipients were asymptomatic. Therefore, although we could not carry out a statistical analysis due to the low number of patients in each group (n = 3 + n = 3), we believe that the differences observed between both groups are suggestive of a causal association of R(+)QF-CMVNR with the severity of CMV infection. This study shows that pretransplant QuantiFERON?-CMV assay predicts the risk of CMV replication after transplantation in solid organ transplant recipients. A complete agreement of the QF-CMV assay with CMV-serology is observed in R(?) recipients since all of them (11/11) are pretransplant QF-CMVNR.