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Geriatr Gerontol Int 2014; ���: ���C���. ""The changes in body composition and biomarker levels that occur during the aging process are complex and remain poorly understood. The present study aimed to evaluate changes in serum C-peptide levels and fat mass-to-lean mass ratio (FM/LM ratio) with increasing age, and to explore http://www.selleck.cn/products/Methazolastone.html the associations between serum C-peptide levels and FM/LM ratio. This was a population-based cross-sectional study that included 3912 participants aged 30�C85?years. Body composition was measured using dual-energy X-ray absorptiometry. Analysis of covariance was used to evaluate how the serum C-peptide level and FM/LM ratio change with increasing age, as well as how the FM/LM http://www.selleckchem.com/products/Nutlin-3.html ratio changes in line with increasing serum C-peptide level. A multiple linear regression analysis was carried out to determine the association between serum C-peptide level and FM/LM ratio. Analysis of covariance showed that serum C-peptide levels, and most regional FM/LM ratios tended to increase in line with increasing age. Total fat mass, total lean mass, percentage total fat mass and total FM/LM ratio were significantly elevated, and percentage total lean mass decreased significantly with increasing serum C-peptide levels in both men and women. Multiple linear regression analysis showed that serum C-peptide level was strongly associated with the total FM/LM ratio. The findings showed that both serum C-peptide level and FM/LM ratio increased with increasing age, and the serum C-peptide level was closely associated with changes in the total FM/LM ratio. Geriatr Gerontol Int 2014; ���: ���C���. ""To investigate frailty in Japanese, Brazilian Japanese descendants and Brazilian older women. The collected data included sociodemographic http://www.selleckchem.com/products/ABT-737.html and health-related characteristics, and the frailty index Kihon Checklist. We analyzed the differences between the mean scores of Kihon Checklist domains (using ancova) and the percentage of frail women (using ��2-test). We carried out a binary logistic regression with Kihon Checklist domains. A total of 211 participants (Japanese n?=?84, Brazilian Japanese descendants n?=?55, Brazilian n?=?72) participated in this research. The Brazilian participants had the highest total Kihon Checklist scores (more frail), whereas the Brazilian Japanese descendants had the lowest scores (P?
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