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718 patients responded (56% of those invited; 39% Hodgkin, 45% non-Hodgkin lymphoma, 16% acute leukaemia). Respondent women were more likely to remain childless than a normal control http://www.selleck.cn/products/azd4547.html population. Self-reported infertility was more likely in men than women [odds ratio (OR) 1��77, P?=?0��001]. Myeloablative therapy increased the likelihood of childlessness (OR 2��48, P?=?0��004). Few attended fertility support services (12%). 24% of men banked sperm and 29% of these used the sample, of which 46% resulted in successful pregnancy. Fertility clinic attendance and sperm storage was more likely post-1990 (OR 4��05, P? http://www.selleckchem.com/products/MK-1775.html glycoprotein, in 140 patients with diffuse large B-cell lymphoma (DLBCL) by tissue microarray (TMA) immunostaining, and gene expression profiling (GEP) in 43 patients. CD43 protein was expressed in 19% of the cases and was strongly related to the non-germinal centre B-cell (non-GCB) subgroup by both TMA and GEP. Patients with CD43(+) DLBCL had an inferior 3-year overall survival (OS) compared to those with CD43(-) DLBCL (50% vs. 76%, P?=?0��01). Within the non-GCB subgroup, patients with CD43(+) DLBCL had a particularly poor 3-year OS (32% vs. 71%, P? http://www.selleckchem.com/products/AZD6244.html of cases in the Western world (Stein et?al, 2008). The current standard treatment for DLBCL is R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone), which can cure about 60% of patients (Ziepert et?al, 2010). The International Prognostic Index (IPI), consisting of five clinical parameters, is the most accepted method for risk stratification of DLBCL patients (The International Non-Hodgkin's Lymphoma Prognostic Factors Project's, 1993; Ziepert et?al, 2010). However, novel biological prognostic markers are also needed to identify high-risk patients.