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Likelihood ratio test p values were computed to compare the likelihood of a null model to the likelihood of the univariate model of interest. In analyses of rare exposures (n http://www.selleckchem.com/products/gsk1120212-jtp-74057.html they were kept in the final analyses. In analyses of both average and total accumulated dose of immunosuppressants, the participants were categorized according to the quartile distribution among controls. For ATG, the 50th percentile was used as cutpoint. Orally administered medications were analyzed both separately and combined with the corresponding intravenous preparations. Because the results were similar, the combined results are presented. Average daily dose comprised only orally administered drugs (except for ATG and OKT3 that are not given orally). When combining orally and intravenously administered drugs, differences in biological availability and potency were taken into account. Corticosteroids were converted to the equivalent http://www.selleckchem.com/products/MDV3100.html dose prednisolone (using conversion factors 8.33 �� bethametasone, 0.25 �� hydrocortisone, 1.25 �� methyl-prednisolone, 1 �� prednisone). Oral corticosteroids were multiplied by 0.82 when added to intravenously administered corticosteroids. Similarily, oral azathioprine was multiplied by a factor 0.3, cyclosporine by 0.25 and cyclosporine microemulsion by 0.38. In the case-control study, to investigate potential independence of associations observed in the univariate model, we adjusted for each of the covariates one by one in a http://www.selleck.cn/products/pd-1-pd-l1-inhibitor-2.html multivariable model. In the cohort of 11 081 transplant recipients followed through 2008, the median follow-up time was 7 years, with a maximum of 38 years (Table 1). Kidney recipients constituted 74% of the patients (n = 8177) but generated 82% of the follow-up time. In total, 153 cases of NHL were observed during 97 853 person-years (Table 2). Compared with the general population, male and female kidney recipients were at a five- to sixfold increased risk of NHL whereas nonkidney recipients were at an about 20-fold increased risk. Young graft recipients below 20 years of age were at a 40-fold (kidney) or 400-fold (nonkidney) risk, whereas among individuals 60 years and older, risks fell to 3- and 13-fold increased, respectively. In the posttransplant period, NHL risks were highest during the first year. Among kidney recipients, a sixfold increased risk persisted after 15 years or more of follow-up. Among nonkidney recipients, the risk was 44-fold increased after 15+ years, although based on small numbers.