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The MEA technique has been described previously elsewhere [18, 19], but in brief, MEA utilises single-use test cells with two pairs of sensor wires. Whole blood is filled into these cells. Thrombocytes are non adhesive in the resting state but when activated, stick to the sensor wires, enhancing the electrical impedance between the wires. These changes in impedance are recorded over 6?min and displayed as a typical curve (Fig.?1). The most important parameter is the area under the aggregation curve (AUC) which represents overall platelet function. The tests were conducted according to the manufacturer��s advice using commercially available test solutions (Dynabyte); http://www.selleck.cn/products/3-methyladenine.html the AUC was determined and resulting data were stored in a computer. The pH of each assay was assessed by an automated blood gas analyser (ABL FLEX-900 blood gas analyser; Radiometer, Copenhagen, Denmark) at 37?��C. Wilcoxon signed rank tests were performed for comparison between measurements. The effects of acidosis on treatment groups were analysed by Friedman tests. Data were http://www.selleckchem.com/products/r428.html analysed using GraphPadPrism (Version 4.02; GraphPad Software Inc., San Diego, CA, USA). Considering a confidence interval of 95% an �� error p of http://www.selleckchem.com/products/PF-2341066.html are demonstrated in Fig.?2. At native pH, hypothermia decreased the AUC insignificantly (p?=?0.092) while DDAVP increased the AUC significantly compared with baseline (p?=?0.034). Acidosis significantly impaired the AUC in both groups regardless of treatment (both p?