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The group recommends that only PSA tests obtained during the last 12 months should be used in the calculation so as to reflect the patient's present and most relevant disease [25]. Retrospective studies have shown that a relatively high percentage of patients with low-risk disease and potential candidates for AS are upgraded and/or upstaged in their final histopathology when they instead undergo immediate RP [26, 27]. Acknowledging, therefore, that the inclusion criteria for AS have a limited accuracy when it comes to selecting patients with true low-risk PCa, it becomes even more important that the progression criteria used when monitoring patients on AS on the one hand are able to identify patients with poor histopathology sufficiently early for curative therapy to be possible, and on the other hand are specific http://www.selleckchem.com/products/INCB18424.html enough to spare patients with true low-risk disease from curative treatment. Only patients who met the predefined progression criteria in the programme were available for a comparison of the final histopathology after RP and the PSAdt during AS. Logically, this comparison has significant limitations since PSAdt was one of the criteria used to select patients for RP. In our comparison, we were not able to establish a correlation between PSAdt and final histopathology; however, had the entire AS cohort eventually http://www.selleckchem.com/products/SB-431542.html undergone RP, a correlation might have existed. Sengupta et?al. [12] found that PCa-specific mortality was greater in patients with a preoperative PSAdt http://www.selleck.cn/products/VX-770.html