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Concentrations of total cholesterol and triglycerides were analysed by enzymatic techniques as described previously [20, 21]. LDL cholesterol and HDL cholesterol concentrations were calculated by formulas validated and described elsewhere [22, 23]. Diabetes mellitus was defined as fasting serum glucose more than 7.0?mmol?L?1 (126?mg?dL?1) or hospitalization before inclusion with diabetes as discharge diagnosis. All laboratory methods were performed with automated multichannel instruments with systems for automatic calibration [21]. Serum creatinine was analysed by a nonkinetic alkaline picrate method (Jaff��) [21], using an AutoChemist-PRISMA (New Clinicon, Stockholm, Sweden) 1985�C1992 http://www.selleckchem.com/products/bmn-673.html and DAX-96 analyzer (Technicon Instruments Corporation, Tarrytown, NY, USA) 1993�C1996. Coefficients of variation for creatinine determinations was http://www.selleckchem.com/products/lee011.html lower as compared with those in the AMORIS population. No direct or indirect adjustment of our creatinine values to standardized creatinine was made. Renal function was classified according to GFR estimated by the Mayo formula (GFR-Mayo) [17], and the simplified MDRD study equation (GFR-MDRD) [14]. GFR was expressed in mL/min per 1.73?m2 body surface area. Chronic kidney disease was defined as GFR 90, 60�C90, 30�C60 and http://www.selleck.cn/products/AZD6244.html infarction. The secondary outcome was all-cause mortality. Follow-up started when the last creatinine value used for estimation of GFR was analysed and ended for myocardial infarction at the time of death, emigration, myocardial infarction or the 31st of December 2002, and for mortality at the time of death, emigration or the 31st of December 2002, whichever came first. The mean follow-up time was 11.6 years. New cases of myocardial infarction were identified from registers of hospital discharges and the Swedish National Cause-of-Death register. A hospital discharge register covering all emergency hospitals in Sweden was available from 1987. From 1964 to 1986, information on hospital discharges was available for certain regions of Sweden, including Stockholm County from 1969, with essentially a complete coverage of the country in 1985.