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The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. We thank Jean-Pierre Raufman, MD (Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine) and Charles D. Howell, MD (Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine) for reviewing our manuscript. ""Starting with the relevance of the Spanish experience, this study analyses the population��s disposition towards organ donation after death by means of a representative survey of the adult Spanish population (N?=?1206, estimated http://www.selleckchem.com/products/PD-0332991.html error ��2.87%, P? http://www.selleckchem.com/products/Everolimus(RAD001).html 50.2% if the deceased��s wishes were unknown and 13.1% even if the deceased opposed donation. Among people who were favourable towards donation, the main motives expressed were the will to save other people��s lives, solidarity and knowing they might someday need a donation. The most important motives for not donating among participants who were against it were the fear of premature organ extraction, of premature pronouncement of death and of mutilation. Reticence to donate is associated with low socio-economic and cultural level, advanced age and high religious commitment; it is also associated with a low perception of transplant efficacy, not directly knowing any transplanted people and the lack of qualified information. The results support diverse potentially effective strategies for promoting donation in the general population. Organ transplantation currently depends on the availability of human organs. Their scarcity means that there is a waiting list of almost 63?000 in the European Union [1], and over 100?000 people in the United States [2]. The process http://www.selleck.cn/products/Bortezomib.html of obtaining organs is clearly conditioned by the resources of health services and by health professionals�� performance in potential donor identification and management tasks. However, in accordance with the current legislation in Western countries, the generation of organs is ultimately subject to a personal or family decision [3], strongly mediated by psychosocial processes. From these premises, there has been an appeal to complement progress in medical�Csurgical procedures with psychosocial research [4�C6], and to date, an important number of studies have been developed that have analysed the factors that affect the diverse phases that lead to donation.