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[27] In those without peripheral arterial disease, there was no difference in strength measures between statin and nonstatin users.[26, 27] Ashfield et?al. found no association between statin use and grip strength in women and men aged 59�C73 years.[28] The conflicting https://www.selleckchem.com/products/poziotinib-hm781-36b.html evidence in relation to statin use and physical performance is possibly caused by inconsistencies in the types of functional tests used, sample sizes, co-morbidities and/or gender of participants.[8, 9, 25, 26] Further, most previous studies have included only a limited range of physical performance measures and none has examined the relationship between statin use and prospectively measured falls. The aims of this study, therefore, were to investigate: (i) whether there are significant associations between statin use and muscle strength, balance and mobility and (ii) whether statin use increases the risk of falls in community-dwelling older people. Five hundred community-dwelling people aged 70 to 90 years participated in the prospective cohort study with a 1-year follow-up for falls. They were randomly recruited from a cohort of 1037 community-dwelling men and women living in eastern Sydney and participating in the first stage of the Sydney https://www.selleckchem.com/products/ganetespib-sta-9090.html Memory and Ageing Study (January 2006 to October 2007).[29] Exclusion criteria were severe neurological, cardiovascular or major musculoskeletal impairments (determined at a baseline physiological assessment) that precluded participants from walking 20?m without a walking aid, and cognitive impairment determined by a score of https://www.selleck.cn/products/cobimetinib-gdc-0973-rg7420.html and cognitive measures by trained research personnel.[30] A complete medical history was recorded, including the presence of medical conditions, medication use and falls history. Participants brought containers for all current medications to the assessment and research staff recorded all medications, including the type and prescribed dosage. Statins used by those in the survey included fluvastatin, pravastatin, rosuvastatin, simvastatin and atorvastatin. Length of statin use and dosage regimens for the different statins were not used in this analysis and no differentiation was made between the types of statin used. The Physiological Profile Assessment (PPA)[18] has been developed by the Falls and Balance Research Group at Neuroscience Research Australia, Sydney and uses an individual's physiological profile to estimate falls risk.