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Although cFGF23 levels fell in both groups, an increase in iFGF23 likely mediated transient and asymptomatic reductions in serum phosphate levels that were observed exclusively in the FCM-treated participants. These data should stimulate additional research into mechanisms http://www.selleckchem.com/products/dabrafenib-gsk2118436.html of FGF23 synthesis and degradation, and the role of iron deficiency and its treatment. As a consultant for Luitpold Pharmaceuticals, Inc., MW developed the study protocol, analyzed the data, and authored the manuscript. MW has also served as a consultant or received honoraria from Abbott, Amgen, Diasorin, Genzyme, Kai, Mitsubishi, Sanofi, Shire and Vifor. TK and DB are employees of Luitpold Pharmaceuticals, Inc. This study was supported by Luitpold Pharmaceuticals, Inc. David Morris, PhD, performed the primary statistical analysis. Maria E Ashton, MS, RPh, MBA, assisted the authors by gathering literature and amassing references for the bibliography. Authors' roles: Study design: http://www.selleck.cn/products/ly2157299.html MW, TAK, and DBB. Study conduct: TAK and DBB. Data collection: TAK and DBB. Data analysis: MW. Data interpretation: MW, DBB. Drafting manuscript: MW. Revising manuscript content: TAK and DBB. Approving final version of manuscript: MW, TAK, and DBB. MW takes responsibility for the integrity of the data analysis. ""It is commonly said that vitamin D should be used to increase calcium absorption. We tested this statement in a dose-response study of vitamin D on calcium absorption. A total of 198 white and African American women, aged 25 to 45 years, with vitamin D insufficiency, serum 25-hydroxyvitamin D (25OHD) http://www.selleckchem.com/products/sch772984.html after 12 months using a single isotope method with radiocalcium45 and 100?mg of calcium. Mean baseline serum 25OHD was 13.4?ng/mL (33.5 nmol/L) and increased to 40?ng/mL (100 nmol/L) on the highest dose of 2400 IU. Using a multivariate regression analysis with significant predictors, baseline absorption, calcium intake, and weight, there was no increase in 12-month calcium absorption compared with baseline on any dose of vitamin D in either whites or African Americans. There was no significant relationship between 12-month calcium absorption and final serum 25OHD. In an analysis of calcium absorption and serum 25OHD at baseline, serum 25OHD levels were divided into groups: 0 to 5, 6 to 10, 11 to 15, or 16 to 20?ng/mL. There was no evidence of a threshold decrease in calcium absorption or serum 1,25 dihydroxyvitamin D (1,25(OH)2D) amongst the lowest groups. Vitamin D doses up to 2400 IU daily did not increase calcium absorption. No threshold level of serum 25OHD for calcium absorption was found at baseline or in the longitudinal study, suggesting that active transport of calcium is saturated at very low serum 25OHD levels