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In accordance with the present findings, it has been shown that cIMT, a surrogate marker of carotid atherosclerosis, is increased in patients with psoriasis compared with controls [10]. However, in contrast to coronary atherosclerosis, cIMT was associated only with age and not psoriasis per se, after multivariate adjustment. The cause of the lack of independent association between increased cIMT and psoriasis is unclear but may be due to a lower risk of stroke compared with myocardial infarction as observed in previous studies; this may suggest a preferential involvement of the coronary arteries rather than carotid arteries in patients with psoriasis [23, 24]. On the other hand, the intermediate disease duration in the http://www.selleck.cn/products/Bortezomib.html current study may limit the statistical power to discern an independent association between cIMT and psoriasis. Previous studies have consistently demonstrated that patients with psoriasis have a higher prevalence of cardiovascular disease risk factors than healthy subjects. The prevalence of cardiovascular disease risk factors was assessed in a UK population-based study in patients with mild (n?=?466?252) and severe (n?=?3854) psoriasis compared with control subjects. The results showed a higher cardiovascular disease risk profile in patients with severe and mild psoriasis compared http://www.selleckchem.com/products/PD-0332991.html with controls: diabetes mellitus (7.1%, 4.4% and 3.3%), hypertension (20.0%, 14.7% and 11.9%), hyperlipidaemia (6.0%, 4.7% and 3.3%), obesity (20.7%, 15.8% and 13.2%) and smoking (30.1%, 28.0% and 21.3%), respectively [25]. In a recent study, Mehta et?al. [8] also demonstrated that patients with psoriasis (n?=?3603) had a higher prevalence of diabetes mellitus (7.5% vs. 5.1%, P? http://www.selleckchem.com/products/Everolimus(RAD001).html power). The prevalence of cardiovascular disease risk factors in Asian patients with psoriasis should be further evaluated in a population-based study. When only subjects without cardiovascular disease risk factors were included in the analysis, there were no significant differences in the prevalence of coronary atherosclerosis or cIMT between patients with psoriasis (n?=?34) and controls (n?=?40). The lack of a significant difference in surrogate markers of atherosclerosis suggests that premature atherosclerosis in patients with psoriasis could be due at least in part to the clustering of cardiovascular disease risk factors.