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43, 95% CI 0.38�C0.49), significantly greater than the 37% decrease in risk per 5-unit increase in BMI in overweight and obese women (RR per 5?kg/m2?=?0.63, 95% CI 0.56?0.71) (p? http://www.selleckchem.com/products/ly2157299.html there was a 32% reduction in hip fracture risk (RR?=?0.68, 95% CI 0.62�C0.73), and for any exercise versus no exercise, there was a 32% reduction in hip fracture risk (RR?=?0.68, 95% CI 0.62�C0.75). The separate effects of BMI and physical activity with hip fracture risk are shown in Figs. 3 and 4. The greatest relative risk was found in inactive women with a BMI of less than 20?kg/m2. Although a progressive decrease in risk of hip fracture was noted with each 5?kg/m2 increment in BMI, active women, irrespective of activity level, were consistently at a lower risk for hip fracture than inactive women within each BMI category. Differences in risk with increasing levels of physical activity were not as clear, and there was no statistically significant interaction between BMI and either strenuous physical activity (p?=?.92) or any physical activity http://www.selleck.cn/products/s-gsk1349572.html (p?=?.87). Several sensitivity analyses were done (Table 4). When analyses were restricted to women without missing data for any of the adjustment variables, results showed similar risk relationships, as did results from a sensitivity analysis that excluded the first 2 years of follow-up. There appeared to be small differences in the pattern of risk of hip fracture according to BMI between current users of HRT and those not currently using HRT, but these differences were not significant (p?=?.15 for interaction). There also were no significant interactions between HRT use and strenuous activity (p?=?.16) or between HRT use and any activity (p?=?.30). Although a sensitivity analysis restricted to nondiabetics gave http://www.selleckchem.com/products/z-vad-fmk.html similar risk relationships as the full sample (Table 4), all analyses were adjusted for diabetic status because diabetics are at an increased risk of hip fracture.35 There were 155 hip fractures among diabetic women, too few for separate sensitivity analyses subdivided by BMI and physical activity. Finally, we considered the differences in risk relationships between two fracture subtypes. The inverse association between BMI and risk of fracture was stronger for fractures that occurred at the neck of the femur than it was for pertrochanteric fractures. There were too few subtrochanteric fractures to repeat a similar sensitivity analysis among this group. In this study of almost a million postmenopausal women followed for an average of 6.