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One major problem in these particular http://www.selleckchem.com/products/Y-27632.html patients was unsatisfying image quality because of rapid vessel movement on the basis of untreatable high heart rates or arrhythmia like atrial fibrillation leading to exclusion of a considerable amount of vessel segments from further analysis [14]. Thus, this study sought to evaluate the clinical feasibility of dual-source computed tomography (DSCT) scanner technology especially with regard to visualization of distal vessel segments to detect significant focal stenosis in HTX patients with ICA as the reference method. We included 51 consecutive heart transplant recipients (43 men, 8 women, mean age: 52.3?��?13.6?years) who underwent DSCTA 1?��?2?days before annual routine ICA as part of the study protocol. Exclusion criteria were http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html as follows: (i) former stent implantation procedure or bypass grafting, (ii) severe renal insufficiency (blood creatinine >1.5?mg/dl), (iii) severe cardiac insufficiency, (iv) previous allergic reaction to iodinated contrast media and (v) unstable clinical conditions. The study protocol was approved by the institutional review board and all patients gave written and informed consent. The mean post-transplant time was 6.9?��?4.1?years (range: 2?weeks to 15?years). Blood creatinine levels were recorded before ICA (baseline value) and the day after DSCTA (mean time interval: 38.1?��?2.4?h). Standard hospital care included adequate hydratation for at least 12?h before and after contrast agent http://www.selleck.cn/products/pexidartinib-plx3397.html application. In addition, every patient received orally N-acetylcystein (600?mg twice daily). Detailed patient characteristics are given in Table?1. The ICA was performed in Judkins technique using a 6-F catheter in a standardized procedure. All acquired images were digitally stored on a hard drive and transferred to an external workstation (HICOR; Siemens Medical Solutions, Erlangen, Germany). For Quantitative Coronary Analysis (QCA) the Quant-Cor QCA software package (Quantcor.QCA; CAAS II, V.5.0; Pie Medical Imaging, Maastricht, Netherlands) was used. At least two orthogonal views were obtained for each coronary angiogram and assessed by one experienced reader blinded to the DSCTA results. Percentage luminal stenosis was recorded and interpreted in a clinical useful scale depending on the QCA results. Thereby significant disease was defined as luminal diameter obstruction ��50% or total vessel occlusion. Nonsignificant disease was defined as arterial lumen irregularity or loss of concentric vessel profile without significant stenosis (
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