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The increasing use of symptom measures at baseline and longitudinally in observational studies and clinical trials could provide data with which to evaluate further the observations reported in the current study. Symptom assessment by the MDASI takes http://www.selleckchem.com/products/INCB18424.html predicting overall survival in patients with advanced cancer. Such symptom�Cbased prognostic information, taken together with physician�Crated PS, may help clinicians gain a sense of the expected near�Cterm survival for individual patients http://www.selleck.cn/products/U0126.html with advanced NSCLC who qualify for chemotherapy. We thank Linda McCrory, RN and Beth Johnson, RN for data collection and Marilyn Morrissey, MPH, for protocol management. We also acknowledge the editorial assistance of Jeanie F. Woodruff, ELS. This study was funded by a grant (R01 CA026582) from the National Cancer Institute (NCI) of the National Institutes of Health (NIH). Neither the NCI nor the NIH had any role in the study design, data collection, analysis, interpretation, or preparation of the report. ""Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group http://www.selleckchem.com/products/PLX-4032.html (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy. Pediatr Blood Cancer 2010;54:663�C669. ? 2009 Wiley-Liss, Inc. With therapeutic advances 80% of children and adolescent cancer patients are expected to become long-term survivors. Current projections are that 1 in 640 adults aged 20�C39 years in the US is a childhood cancer survivor 1. Although antineoplastic therapy is commonly associated with acute and often reversible hepatotoxicity, there is little follow-up on long-term liver health in survivors of adult or childhood cancer. Acute or subacute hepato-biliary injury is recognized with varying incidence following radiation, multiple chemotherapies, or hematopoietic stem cell transplantation (HSCT) 2, 3.