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The model outputs a common odds ratio (OR) for each predictor variable, which is interpreted as the relative odds of a participant being higher on the hand function variable across the entire range of hand function levels. Pseudo R2 values, which assess the fit of the ordinal logistic models used to predict the odds of higher levels of hand function, were assessed for each model. These measure the ratio of the log estimated likelihoods from the model with and without predictors, and have values between 0 and 1 such that higher values indicate better model fit. All analyses were undertaken using STATA 9 (StataCorp., College Station, TX, USA). Video data were provided by 144 families. All participants https://en.wikipedia.org/wiki/Mephenoxalone had a clinical diagnosis of Rett syndrome, their mean age being 14?years 10?months (SD 7y 10mo; range 2y�C31y 10mo). Thirty-six participants were younger than 8?years, 25 were aged between 8 and under 13?years, 40 were aged 13 to under 19?years, and 43 were aged 19?years or older. A MECP2 mutation was identified in 110 (80.9%) of the 136 participants tested. Mutation status was unknown or not tested in eight participants. The early-truncating, p.R106W, p.R306C, and large-deletion mutations were identified in approximately 5% of participants; the C-terminal, p.R133C, p.R168X, p.R255X, p.R270X, p.R294X, p.T158M, and other mutations were identified in approximately 10% of http://www.selleckchem.com/products/pembrolizumab.html participants (Table?II). The video package was sent to the families and carers of 246 females with Rett syndrome, and 144 families returned a video on one or two occasions, giving an overall response of 58.5%. To assess the representativeness of our sample, the age group at the time of video for the http://www.selleckchem.com/products/atezolizumab.html 144 participants was compared with the age group mid-way through 2004 for the 153 females known to the ARSD for whom a video had not been provided, irrespective of whether families had received a video package (some families were not sent a video package because they declined to participate or because the person with Rett syndrome subsequently died). Participants for whom a video was provided were a little more likely to be younger than 8?years (25.0% vs 17.6%) and less likely to be aged 8 to