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These were used in substitution of the MELD score because international normalized ratio was not reported to UNOS prior to 2002. Univariate categorical comparisons were performed using the chi-square test. Continuous variables were compared using the Student��s t-test. Univariate, unadjusted survival was estimated using the Kaplan�CMeier http://www.selleckchem.com/products/z-vad-fmk.html technique. Adjusted multivariate survival models were constructed using Cox proportional hazards techniques. Risk stratification for donors in multivariate models was adjusted using the donor risk index (DRI) [16]. The level of statistical significance in type 1 error was set at ��0.05 and all statistical tests were two-sided. All statistical analyses and dataset manipulations were performed with sas, version 9.1 (Cary, NC, USA). No local institutional review board approval was required for use of the deidentified UNOS dataset. A total of 56?275 liver transplantations were analyzed; 934 (1.7%) of all successful liver donations involved an HCV+ donor. Figure?1 shows that the frequency of HCV+ donors used for liver transplants has increased steadily over recent years. Table?1 shows the characteristics of transplants involving HCV+ and HCV? donors. In total there were 19?496 HCV+ recipients and 934 HCV+ donors; 79.3% of HCV+ donor grafts went to HCV+ recipients compared to 33.9% of HCV? donors going to HCV+ recipients (P? http://www.selleckchem.com/products/ly2157299.html transplants involving HCV+ donors and HCV? donors. Compared with HCV? grafts, patients receiving HCV+ grafts were slightly older (51.8 vs. 50.6?years, respectively, P? http://www.selleck.cn/products/BIBW2992.html many significant differences between HCV? and HCV+ donors. Compared with HCV? donors, HCV+ donors were older (41.4 vs. 37.0?years, P?