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This study was the first to demonstrate a lower rate of CMV infection in patients treated with Tac vs. those treated with CsA within a standard immunosuppressive regimen after HTx. Tacrolimus may reduce the possibility of developing CMV infection and it may as well delay its occurrence. In view of the results, we consider it is justified to use tacrolimus instead to cyclosporine in those patients at higher risk of developing CMV infection and those in which this infection is difficult to manage. This work was been translated with a no-conditions grant from Roche Pharma. Our thanks to M��nica Cebri��n for her collaboration. M. Rodr��guez-Serrano analyzed and interpreted the data and wrote the article. I. S��nchez-L��zaro conceived and designed the study. He http://www.selleckchem.com/products/MK-2206.html analyzed and interpreted the data and wrote the article. L. Almenar Bonet conceived and designed the study. He critically reviewed and approved the article. L. Mart��nez-Dolz, M. Portol��s Sanz, M. Rivera Otero, and A. Salvador Sanz critically reviewed and approved the article. All authors have agreed to submission of the article in its present form. ""Some cardiac transplant programs may upgrade listed patients to United Network for Organ Sharing (UNOS) 1A-status during the holidays. Whether more transplants actually occur during holidays is unknown. We assessed rates of single-organ heart transplantation from 2001 to 2010 for recipients age ��18?yr using the UNOS database. Patients were stratified by transplantation during holiday (��3?d, n?=?2375) and non-holiday periods (n?=?16?112). Holidays included Easter/Spring break, Memorial Day, July 4th, Labor Day, Thanksgiving, and Christmas/New Years (winter holidays). Secondary analysis assessing transplant rates across seasons was also completed. Donor and recipient characteristics were similar between groups. Compared with non-holidays, July 4th had higher transplant rates (5.69 vs. 5.09?transplants/d, p?=?0.03) while the winter holiday had lower transplant rates (4.50 vs. 5.09?transplants/d, p?