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CPT1B was expressed at the highest levels in LD and SF; CPT1A expression was highest in the liver, pancreas and duodenum. These results are in accordance with previous results determined in humans and rats (McGarry & Brown 2000; McGarry & Foster 1979). Both the CPT1A and CPT1B genes were highly expressed in LD, SF, liver and duodenum, suggesting that CPT1 might have a close relationship with fat metabolism and IMF deposition, providing us with a basis for regulating IMF deposition. http://www.selleck.cn/products/ly2157299.html Fatty acid ��-oxidation is an effective way to supply tissues with energy, especially for heart and skeletal muscle, with CPT1 playing an important role in this process (Kim & Simon 2004). We found that both CPT1A and CPT1B mRNA expression levels in the LD of Jinhua pigs were significantly higher than in Landrace pigs. This suggests that fatty acid ��-oxidation in the LD of Jinhua pigs was more active than in Landrace pigs. At the same time, however, the IMF content in Jinhua pigs was significantly higher than in the Landrace breed. We also found that there was a great difference in fiber types of the LD between Jinhua and Landrace pigs (Guo et?al. 2011). It is possible that the differences in CPT1A and CPT1B gene expression levels between the two breeds can be partially attributed to the fact that there are more type I and type IIA muscle fibers in the http://www.selleckchem.com/products/dabrafenib-gsk2118436.html LD of Jinhua pigs. The result of this is that there are more free fatty acids being continuously transported to the muscle to supply energy after oxidation. These are then absorbed by IMF cells for the synthesis of triglyceride. They also promote IMF deposition during fatty acid ��-oxidation following transfer of long-chain fatty acids from SF to the mitochondria by CPT1. Additionally, CPT1 is closely associated with body fat deposition; increased body fat correlates with lower CPT1A and CPT1B mRNA expression levels (Kim et?al. 2000a,b). SF is an important component of fat metabolism and deposition. We showed that CPT1A and CPT1B expression levels in SF of Jinhua pigs were significantly lower than in Landrace pigs (P? http://www.selleckchem.com/products/sch772984.html Jinhua pigs. This possibly explains why the SF of Jinhua pigs is thicker compared with Landrace pigs. CB1 is the main receptor of endogenous cannabinoids during lipid signaling. It plays an important role in the metabolism of body fat, insulin resistance, glucose uptake, mechanisms related to diabetes, obesity and livestock fat deposition. Many studies have indicated that CB1 exists in adipose tissue and regulates fat deposition and differentiation of fat cells (Bluher et?al. 2002; Bensaid et?al. 2003; Douglas et?al. 2005; Pagano et?al. 2007). Matias et?al. (2005) showed that treating 3T3-F442A cells with HU210, a CB1 agonist, increased fat deposition in cells.