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All patients had anti-embolism compression stockings applied before TURP until discharge. The operations were performed by consultant urologists or accredited registrars. The parameters recorded were age, American Society of Anesthesiology (ASA) score, indication for TURP, whether taking antiplatelet or anticoagulant agents and if these were ceased perioperatively, indication for antiplatelet or anticoagulant agents, weight of resected tissue, duration of resection, histopathology, recorded occurrence of bleeding complications, and vascular events occurring within 28 days of the operation, namely acute coronary or cerebrovascular events. Bleeding complications were defined as prolonged http://www.selleck.cn/products/Cisplatin.html bladder irrigation, clot retention requiring recatheterization, anaemia requiring blood transfusion, haematuria requiring operative intervention, and hypovolaemic shock. Results were analysed using SPSS version 16 software, using Student's t-test to seek differences between the means in normally distributed data and the chi-squared statistic for contingency tables. During the study period 170 patients underwent TURP and the notes with adequate follow-up of 163 were available for review, with 91, 65 and seven cases in groups 1, 2 and 3 respectively. A total of 40 patients in groups 2 and 3 were on aspirin alone and this was ceased in 34. Table?1 illustrates the demographic data and that the groups were comparable. http://www.selleckchem.com/products/3-methyladenine.html All except three of the patients on antiplatelet agents were on the drug(s) for secondary prevention. Only one patient in group 3 was on clopidrogel; the rest were on aspirin. As demonstrated in Table?2 there was a statistically significant increase in bleeding-associated morbidity in groups 2 (13/65 patients) and 3 (6/7 patients) compared with the control group (9/91 patients) (P http://www.selleckchem.com/products/PD-0325901.html for TURP and the other three were readmitted within 28 days. All these six by definition were still on their drugs. Cardiovascular and cerebrovascular events were only seen in group 2 (6/65), at a significantly higher rate than the event rate in the other groups (P�� 0.01). The patients who suffered these complications did not figure in the group with bleeding complications (Fig.?2). The first three were seen during the admission for TURP and the other three resulted in readmission within 28 days.