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08; p? http://www.selleckchem.com/products/smoothened-agonist-sag-hcl.html at all doses used, and only the highest dose (0.03?mg/kg) decreased the activity in saline-treated mice. A two-way ANOVA revealed a main effect of Sulpiride [F(6,126)?=?16.3, p? http://www.selleck.cn/products/SP600125.html of the saline group. The highest dose (30?mg/kg) affected also activity levels in saline-treated mice. The effects of SCH-23390 (panel A) and Sulpiride (panel B) on the locomotor activity of mice repeatedly treated with saline or ethanol are shown in Fig.?2. The results of the SCH-23390 experiment are described in the following discussion. Analysis of the data from the Habituation Days revealed a main effect of habituation [F(1,56)?=?118.00, p? http://www.selleckchem.com/products/epz015666.html an increase in locomotor activity over treatment, suggesting the development of dopaminergic supersensitivity. Mice treated with SCH-23390 plus saline demonstrated a higher increase in locomotor activity (215.75?��?41.03%) when compared to the mice treated with SCH-23390 plus ethanol (87.26?��?20.25%) (t?=?2.78, p?