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Only comorbidities consistently listed during the entire period were included in the final tabulation of data. Differences were assessed using t-test and anova with the Holm�CSidak or Dunn's method to correct for multiple comparisons (SigmaStat 2.0; SPSS, Chicago, IL, USA). About 200?000 annual encounters listed gastroparesis as diagnosis, with it being the primary diagnosis in slightly less than 10%. The majority of emergency encounters resulted in hospitalization (Fig.?1A). Consistent with the known epidemiology of gastroparesis, women accounted for the majority of emergency encounters (65.7?��?0.2%) with admission rates not differing based on gender (women: 75.7?��?1.2% vs men: 78.1?��?1.0). As shown in Fig.?1B, most patients were young and middle-aged adults. When normalized by the contribution of each cohort in the overall volume of emergency encounters, admission rates significantly increased with age (Fig.?1B). This age dependence of hospitalizations points at the importance of comorbid conditions, which were examined next. The most common comorbidities could be grouped into separate categories, with diabetes mellitus being most frequently noted, followed by cardiovascular problems, disorders of electrolyte or fluid homeostasis or renal failure, other gastrointestinal illnesses, infections, and complications of medical treatment (Fig.?2). Interestingly, an associated diagnosis of diabetes mellitus did not increase the risk of admission, whereas heart or renal failure, gastrointestinal bleeding, coexisting infections, complications of prior treatment, and �C in gastroparesis as primary diagnosis �C mood disorders increased the likelihood of inpatient treatment (Table?1). Mortality of patients admitted for gastroparesis was at 1.26?��?0.13% with significant differences between admissions for gastroparesis as primary and secondary diagnosis (0.44?��?0.03% vs 1.26?��?0.13%; P?