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When examined by age group, the respective 3-year and 5?year-OS rates for those treated with R-CHOP were 77% and 76% in the young patients, 62% and 55% in the elderly patients and 44% and 33% in the very elderly patients (Fig?1). Among matched patients, R-CHOP was associated with a significant increase in OS of 9% at 3?years compared to CHOP alone (68% vs. 59%; HRdeath?=?0��78, P?=?0��0004), and 8% at 5?years (62% vs. 54%; HRdeath?=?0��78, P?=?0��0004). The survival advantage associated with the use of rituximab in different age groups is summarized in Table?2 and illustrated in Fig?2. Among young patients, rituximab was associated with an 8% better 3-year http://www.selleckchem.com/products/LY294002.html OS (77% vs. 69%; HRdeath?=?0��70, P?=?0��002), which was maintained at 5?years (76% vs. 67%; HRdeath?=?0��70, P?=?0��002). Similar results were found for patients aged 60�C79?years, with rituximab-treated patients having superior OS at 3?years (58% vs. 50%; HRdeath?=?0��84, P?=?0��09) and 5?years (52% vs. 41%; HRdeath?=?0��81, P?=?0��02). In the very elderly, R-CHOP was also associated with an increase in 3-year survival (47% vs. 32%; HR death?=?0��73, P?=?0��18), which had attenuated by 5?years (32% http://www.selleck.cn/products/wortmannin.html vs. 27%; HRdeath?=?0��82, P?=?0��36). This was not statistically significant although the absolute improvement in survival and relative reduction in mortality were comparable in magnitude to the results seen among younger patients. The overall 1-year hospitalization rate was significantly greater for patients treated with CHOP alone than R-CHOP (67��2% vs. 61��2%, P? http://www.selleckchem.com/products/CHIR-99021.html patients receiving rituximab (0��9% vs. 0��3%, P?=?0��09), while there was no significant increase in the risk of hospitalization for hepatitis reactivation, febrile neutropenia, or other infectious, cardiac, pulmonary, or gastrointestinal diagnoses with the addition of rituximab. Comparisons of hospitalization rates within age strata of matched patients (