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The minimal level of significance was P? http://www.selleckchem.com/products/MK-1775.html substrate of SIRT1) showed a marked decrease in acetylated state of p53 in SRT1720-treated MM cells (Fig?1B). Our data is in agreement with previous reports showing that SRT1720-induced biological effects occur via SIRT1 (Bhardwaj et?al, 2007; Yoshizaki et?al, 2009; Funk et?al, 2010). Human MM cell lines (MM.1S, MM.1R, RPMI-8266, LR-5, INA6, KMS12, U266) were treated with various concentrations of SRT1720 for 24?h, followed by assessment for cell viability using MTT assays. A significant concentration-dependent decrease in viability of all cell lines was noted in response to treatment with SRT1720 (Fig?1C; http://www.selleckchem.com/products/AZD6244.html P? http://www.selleck.cn/products/azd4547.html melphalan, bortezomib, or lenalidomide and were treated for 24?h with SRT1720, followed by assessment for cell viability. A significant decrease in cell viability of all patient tumour cells was noted after SRT1720 treatment (Fig?1D; IC50 range: 3�C5?��mol/l; P?