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1100 Regulators of Bone Formation in Postmenopausal Osteoporosis: Effect of Bisphosphonate Treatment.Richard Eastell, Rosemary Harmon, Fatma Gossiel*. University of Sheffield, United Kingdom The Wnt signalling pathway is essential for the regulation of bone formation. Serum based immunoassays have recently been developed to measure two key regulators of Wnt signalling, namely Dickkopf-1(Dkk-1) and sclerostin. Postmenopausal osteoporosis is associated with an increase in bone resorption and bone formation. Treatment with oral bisphosphonates results in a decrease in bone formation markers. It is not http://www.selleckchem.com/products/Adriamycin.html known whether levels of Dkk-1 and scelrostin are increased in postmenopausal osteoporosis and decrease with bisphosphonate treatment. The aims were to determine whether 1) Dkk-1 and sclerostin are decreased in postmenopausal osteoporosis and 2) bisphosphonate treatment of postmenopausal osteoporosis results in an increase in these regulators of bone formation. We recruited http://www.selleck.cn/products/dabrafenib-gsk2118436.html 50 postmenopausal women (mean age 68: range 55 to 85 years), with a BMD T-score of http://www.selleckchem.com/products/DAPT-GSI-IX.html women. This may reflect the impairment of bone formation relative to bone resorption in osteoporosis. Treatment of postmenopausal osteoporosis with oral bisphosphonates results in a decrease in bone turnover as expected. However, there was no increase in Dkk-1 and sclerostin. Disclosures: Fatma Gossiel, Proctor and Gamble, IDS and Biomedica: Research support, 9 1101 Risedronate Reduces Deterioration of Cortical Bone Microarchitecture Accompanying Menopause.Ego Seeman*1, Babul Borah2, Roland Chapurlat3, Dieter Felsenberg4, Lynn Darbie5, Rene Rizzoli6. 1Austin Health, University of Melbourne, Australia, 2Procter & Gamble Pharmaceuticals, USA, 3E.