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As such, we undertook a post hoc analysis to examine relative and cumulative steroid exposure, within the confines of the SPLIT database. First, we first examined whether prednisone use in the first 2 years following LT might predict long-term http://www.selleck.cn/products/BafilomycinA1.html BP status, but no association was observed (p = 0.117). Next, as a surrogate for cumulative steroid exposure, we analyzed whether two successive visits with recorded steroid use increased the risk of elevated BP compared to a single visit: indeed, there was 2.8-fold greater risk of measuring an elevated BP with prolonged steroid exposure (Table S5). This study demonstrates that elevated BP measurements exist in as many as 27.5% of pediatric LT patients aged 5 years or more and at least 5 years post-LT. It shows a protective effect of younger age at transplant http://www.selleckchem.com/products/blz945.html to evaluate BP and other cardiovascular risk factors rigorously. According to our data, children who are transplanted before the age of 1 year seem to be spared from the risk of long-term BP elevation as compared to those transplanted in early childhood. We might have predicted this finding based http://www.selleckchem.com/products/hydroxychloroquine-sulfate.html on studies suggesting that younger patients have a lower incidence of CNI-induced hypertension than older patients (12), except for the fact that children transplanted after the age of 8 may do better than their peers transplanted between the ages of 5 and 7, a result which speaks against a linear effect of age. In this series, the role of age at transplant in the susceptibility to develop elevated BP is unclear. Indeed, the age group ��4 years is mostly comprised of infants less than 1 year of age who are transplanted early in life for biliary atresia and who have been shown to be less susceptible to hypertension (20). The univariate analysis confirmed these findings since age