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Post-mortem investigations confirmed antenatal findings in 8/9 cases with severe ventriculomegaly (posterior horn measurement >15?mm), whereas only 2/7 in which ventriculomegaly was not confirmed had severe ventriculomegaly. Post-mortem examination, both by traditional neuropathological examination, and post-mortem MRI may fail to confirm prenatal ventriculomegaly in around half of cases. The post-mortem MRI findings indicate that this is due to resolution of ventriculomegaly rather than autopsy artefact, and is presumably a consequence of post-mortem fluid redistribution. Parents should be advised before termination of pregnancy that post-mortem confirmation of ventriculomegaly, especially in mild cases, may not be possible. Antenatal MRI may be a better approach for confirming http://www.selleckchem.com/products/XL184.html prenatal ultrasound findings. ? 2013 John Wiley & Sons, Ltd. ""This study aimed to determine the postnatal outcome of congenital malformations in a tertiary care hospital of India. This was a prospective study of all women with prenatally detected major congenital malformations. Postnatal follow-up of live born babies was carried out for 1?year. There were 574 cases with major congenital anomalies, 523 of which were fully followed. Only 69 women (13.6%) had the initial scan before 20?weeks of gestation. Craniospinal defects were the most common (42.7%), followed by genitourinary anomalies (28%). There was no live birth in cases such as anencephaly, iniencephaly, bilateral renal agenesis, gastroschisis, and cystic hygroma. Survival at 1?year was less than 25% in spina bifida, bilateral http://www.selleck.cn/products/MLN8237.html cystic kidneys, complex cardiac disease, and non-immune hydrops fetalis. In cases with mild hydrocephalus or unilateral and mild renal disease, the survival was over 75%. In India, the majority of congenital anomalies present late in gestation. Although fetal outcome is invariably poor for severe defects, existing legislation in the country leaves pregnancy continuation as the only option. ? 2013 John Wiley & Sons, Ltd. ""To quantify the intergenerational http://www.selleckchem.com/products/CP-690550.html effects on intrauterine growth in pregnant women who were themselves small for gestational age (SGA) at birth. A retrospective case control was carried out on infants born in the period 1 January 2009 to 31 March 2009 at the Sant'Orsola Hospital, Bologna. Out of 958 infants, 707 met the criteria for inclusion in the study. After calculation of the percentiles stratified for gestational age at delivery, 68 cases were classified as SGA. Logistic regression analysis was used as the multivariable tool for calculating the bearing of each covariable on the outcome (SGA), including smoking and the presence of an SGA in previous pregnancies. A total of 28.6% of the infants of SGA women were SGA compared with 8.6% of the children of non-SGA women (p-value