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Health care providers should be aware of the importance of monitoring iron burden with timely initiation of treatment and ongoing adjustments to transfusion methods and/or chelation regimens in response to these measurements. The primary aim of SWiTCH, a multicenter intervention trial, was to compare alternative therapy (hydroxyurea and phlebotomy) with standard therapy (transfusions and chelation) for the prevention of secondary stroke and reduction http://www.selleck.cn/products/MLN8237.html of transfusional iron overload in pediatric subjects with SCA and previous stroke. The SWiTCH study design is described in detail elsewhere [11]. Briefly, children ages 5 to http://www.selleckchem.com/products/XL184.html least 500 ng/mL. At study entry, medical history was taken including data on stroke and other medical complications such as heart and liver disease. Data on transfusion duration and method were collected. Transfusion methods were characterized as simple, partial exchange (manual removal of a determined amount of blood followed by packed red cell transfusion), and erythrocytapheresis (automated red cell exchange). Additional data collection included chelation history (chelator type, dosage and duration of use), and current and prior medications used. Baseline laboratory studies included complete blood count with white blood cell differential and reticulocyte count obtained locally and hemoglobin electrophoresis with quantification of Hb A, S and F levels, chemistry panel, and serum ferritin measured at a central laboratory (Georgia Health Sciences University, Augusta, GA). Liver biopsy was performed and analyzed for LIC by inductively coupled plasma-mass spectrometry at Mayo Medical Laboratories, Rochester, MN. Descriptive statistics http://www.selleckchem.com/products/CP-690550.html (mean, standard deviation, median, range, and frequency) were performed for demographic variables, transfusion history, chelation history, and baseline laboratory values. LIC values were log-transformed due to a skewed distribution of values. Pearson product-moment correlations were implemented for continuous variable relationships and for significance testing. Independent sample t-tests were computed for comparisons of categorical predictors (chelation type, splenomegaly, transfusion type) with continuous outcomes (ferritin, LIC, and hemoglobin S levels).