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TSH receptor-null mice present less BMD than controls with supplementation of thyroid hormone or not, and accumulating evidence suggests that TSH directly inhibits osteoclastogenesis to suppress bone turnover and increases bone mass in rodents. However, it is yet uncertain if this is the case in human. The aim of this study is to clarify whether or not circulating TSH is correlated with BMD in human even in the presence http://www.selleck.cn/products/ly2157299.html of inappropriately high level of serum thyroid hormone. To this end, we examined BMD with DXA and biochemical bone markers in 21 patients with TSH producing pituitary adenoma (TSHoma) but without any other hormonal disorders, because circulating TSH is active even in the presence of thyrotoxicosis in TSHome patients. Serum free thyroxine (FT4), free triiodethyronine (FT3), TSH, bone markers, bone alkaline phosphatase (BAP), osteocalcin (OC), urinary NTX (uNTX) and deoxypyridinoline (DPD), and lumbar BMD (Z-score) before surgery were measured. Nor FT3 or FT4 but TSH was correlated with lumbar BMD (r=0.614, p=0.003). Bone markers were all positively correlated with either serum FT3 or FT4 (p http://www.selleckchem.com/products/dabrafenib-gsk2118436.html indicate that, independent of thyroid hormone, TSH is involved in bone metabolism to increase BMD in TSHoma patients. This is the first report suggesting direct anabolic effects on bone of TSH in human. Although the mechanism is unknown yet, TSH itself may have anabolic effects on bone in human. Disclosures: Nobuaki Ito, None. This study received funding from: Okinaka Memorial Institute for Medical Research MO0354 Vitamin D Levels and Incident Frailty Status in older Women.Kristine Ensrud*1, Susan Ewing2, Lisa Fredman3, Marc Hochberg4, Jane Cauley5, Teresa Hillier6, Steven Cummings7, Kristine Yaffe2, Peggy Cawthon8. 1 Minneapolis VA Medical Center / University of Minnesota, USA, 2 University of California - San Francisco, USA, 3 Boston University, USA, http://www.selleckchem.com/products/sch772984.html 4 University of Maryland School of Medicine, USA, 5 University of Pittsburgh Graduate School of Public Health, USA, 6 Kaiser Center for Health Research, USA, 7 San Francisco Coordinating Center, USA, 8 California Pacific Medical Center Research Institute, USA Vitamin D deficiency and frailty are increasingly common with aging, but the association between these conditions is uncertain. To determine whether non-frail older women with lower serum 25-hydroxyvitamin D (25(OH)D) levels are at increased risk of greater frailty status at follow-up, we measured 25(OH)D levels (liquid chromatography-tandem mass spectroscopy) in 4242 non-frail women (mean age 75.9 years) at baseline and re-examined frailty status 4.5 years later.