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Our results identify molecular and cellular contractile dysfunction in skeletal muscle that may contribute to reduced physical function with muscle disuse, with sex-specific differences that may explain a greater disposition towards disability in women. Physical inactivity that accompanies ageing and disease may hasten disability by reducing skeletal muscle contractility. http://www.selleckchem.com/products/SRT1720.html To characterize skeletal muscle functional adaptations to muscle disuse, we compared contractile performance at the molecular, cellular and whole-muscle levels in healthy active older men and women (n?=?15) and inactive older men and women with advanced-stage, symptomatic knee osteoarthritis (OA) (n?=?16). OA patients showed reduced (P? http://www.selleckchem.com/products/Adrucil(Fluorouracil).html sex-specific differences (P?��?0.05) in myosin�Cactin cross-bridge kinetics. Additionally, cross-bridge kinetics were slowed in MHC I fibres in OA patients (P? http://en.wikipedia.org/wiki/MERTK reductions in women with knee OA (P?