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Hypothesis/Objectives: To identify demographic and historical factors associated with chronic cough in dogs, and associations between the characteristics of cough and diagnosis. Animals: Dogs were patients of an academic internal medicine referral service. Coughing http://www.selleckchem.com/products/pf-06463922.html dogs had a duration of cough ��2 months (n = 115). Control dogs had presenting problems other than cough (n = 104). Methods: Owners completed written questionnaires. Demographic information and diagnoses were obtained from medical records. Demographic and historical data were compared between coughing and control dogs. Demographic data and exposure to environmental tobacco smoke (ETS) also were compared with hospital accessions and adult smoking rates, respectively. Characteristics of cough were compared among diagnoses. Results: Most coughing dogs had a http://en.wikipedia.org/wiki/MRIP diagnosis of large airway disease (n = 88; 77%). Tracheobronchomalacia (TBM) was diagnosed in 59 dogs (51%), including 79% of toy breed dogs. Demographic risk factors included older age, smaller body weight, and being toy breed (P http://www.selleckchem.com/products/AZD1152-HQPA.html data were analyzed with a Wilcoxon rank-sum tests. Sensitivities of diagnostic tests were calculated. Results: There were 106 cows and 6 bulls (median age 5 years) examined for anorexia (34%), weight loss (16%), and fever (14%). The sensitivities of antemortem diagnostic tests performed were peripheral lymph node (PLN) wedge biopsy, 100%; surgical exploration and biopsy, 100%; pleurocentesis, 80%; pericardiocentesis, 67%; PLN fine-needle aspirate, 41%; abdominocentesis, 33%; and cerebral spinal fluid tap, 19%. Median peripheral blood lymphocyte count was 4,900?cells/��L, 10% of cattle were leukemic and 25% had lymphocytosis according to the Bendixen Key.