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These data indicate that these two SNPs should not be used to select patients https://www.selleckchem.com/products/epz-5676.html for single agent rituximab and raise additional questions regarding the mechanism of rituximab cytotoxicity. 197 SIGNIFICANCE OF THE QUANTITATIVE BCL2/IGH@ REARRANGEMENT EVALUATION IN PATIENTS AFFECTED BY FOLLICULAR LYMPHOMA AFTER CONVENTIONAL TREATMENT: THE ANCILLARY STUDY OF THE FIL-FOLL05 TRIAL S. Galimberti,1 S. Luminari,2 E. Ciabatti,1 A. Dondi,2 M. Ladetto,3 P. Piccaluga,4 I. Del Giudice,5 A. Gazzola,4 L. Monitillo,3 B. Mantoan,3 I. Della Starza,5 M. Cavalli,5 C. Mannu,4 G. A. Palumbo,6 L. Marcheselli,2 U. Vitolo,3 G. Gaidano,7 A. M. Carella,8 M. Petrini,1 M. Federico.2 1Clinical and Experimental Medicine, Hematology, Pisa, Italy; 2University of Modena, Oncology, Modena, Italy; 3Citt�� della Scienza e della Salute, Hematology, Torino, Italy; 4Department of Experimental, Diagnostic, and Specialty Medicine, Hemato-pathology, Bologna, Italy; 5Department of Cellular Biotechnologies and Hematology, Hematology, Roma, Italy; 6Azienda Ospedaliera ��Ferrarotto��, Hematology, Catania, Italy; 7Azienda Ospedaliero-Universitaria della Carit��, Novara, Italy; 8Azienda Ospedaliera Universitaria San Martino, Hematology, Genova, Italy. The role of the quantitative assessment of BCL2/IGH@ in patients affected by follicular lymphoma is still a matter of debate. Other authors previously reported that patients with low amount of BCL2/IGH@ had a significant advantage in event-free survival (Rambaldi https://www.selleck.cn/products/Staurosporine.html A, 2005). In the present study, we report about https://www.selleckchem.com/products/ly2109761.html the significance of the quantitative BCL2/IGH@ assessment at diagnosis and after treatment. Results from the qualitative assessment have been already reported at ASH 2012 (Galimberti S, 2012). In the FOLL05 trial, conducted by the Fondazione Italiana Linfomi (FIL), 504 untreated patients were randomized to receive R-CHOP, R-CVP, or R-FM (Clinical trial.gov NCT00774826). Quantitative PCR was performed by the four laboratories of the ��FIL MRD NETWORK�� (Bologna, Pisa, Roma, and Torino, Italy), according to European guidelines (Ladetto M, 2001, van der Velden, 2007). The sensitivity was 1:10?5. At the enrollment, quantitative PCR was performed in 105 cases; the median value was 3?��?10?3 copies (range: ��?10?4copies (p?=?0.033). Moreover, cases displaying values