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Lc/Ct.TV) upon ibandronate treatment. However, a significant increase in the mean single lacunar volume (+13.3%; p=0.02) was observed. We interpreted the treatment dependent increase in single lacunar size as a sign of bone adaptation to possibly altered matrix strain due to a potentially increased matrix stiffness. Disclosures: Heinrich Resch, None. SU0365 Altered Bone Matrix Composition in Premenopausal Women With Idiopathic Osteoporosis as Determined by Raman and FTIR Microspectroscopy.Birgit Buchinger1, Sonja Gamsjaeger1, Adi Cohen2, Emily Stein3, David Dempster4, Halley Rogers2, Robert Recker5, Joan Lappe5, Thomas Nickolas2, Hua Zhou6, Donald McMahon3, Eleftherios Paschalis*7, Elizabeth Shane3, Klaus Klaushofer8. http://www.selleck.cn/products/s-gsk1349572.html 1Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK, & AUVA Trauma Centre Meidling, Hanusch Hospital, Austria, 2Columbia University Medical Center, USA, 3Columbia University College of Physicians & Surgeons, USA, 4Columbia University, USA, 5Creighton University Osteoporosis Research Center, USA, 6Helen Hayes Hospital, http://www.selleckchem.com/products/z-vad-fmk.html USA, 7Ludwig Boltzmann Institute for Osteology, Austria, 8Hanusch Hospital, Austria Idiopathic osteoporosis (IOP) in premenopausal (PreM) women is an uncommon disorder in which fragility fractures and/or low bone mineral density (BMD) occur in otherwise healthy women with normal gonadal function. It is widely accepted that several aspects of bone quality are important contributors to bone strength. In this regard, we have reported that PreM women with IOP have thin cortices and cancellous microarchitectural deterioration and we have also found reduced mineralization of bone matrix by quantitative backscattered electron imaging (qBEI). The purpose of this study was to examine bone mineral and collagen quality in IOP. Included were 59 PreM women, 31 healthy Controls with normal BMD http://www.selleckchem.com/products/ly2157299.html (Z-score >-1.0) at all sites and 28 with IOP, 17 with Fractures and 11 with Low BMD (Z-score