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Three groups received intraperitoneal injections of irinotecan at increasing doses of 25 mg/kg, 50 mg/kg, or 100 mg/kg on Days 1, 5, and 9 of a 28-day cycle. Each group was kept in a separate cage. Two mice in the control group died. All 6 mice that received oxaliplatin at doses of 10 mg/kg and 14 mg/kg suffered clinically from severe neuropathy (unstable and wide base gait) and eventually died. In all 3 irinotecan treatment groups, the mice experienced severe diarrhea. The groups of control mice and mice that received oxaliplatin 6 mg/kg were clinically uneventful. Animals were killed on Day 29. On liver analysis, total fat content was 65.3 mg/g, 73.6 �� 0.1 mg/g, 73.2 �� 0.1 mg/g, and 73.5 �� 0.2 mg/g in the control group and in the irinotecan treatment groups at doses of 25 mg/kg, 50 mg/kg, and 100 mg/kg, respectively. In the group that http://www.selleckchem.com/products/blz945.html received oxaliplatin at a dose of 6 mg/kg once weekly up to a total dose of 24 mg/kg, the liver fat content was 126.3 �� 0.2 mg/g, which was comparable to the level achieved in previous in vivo studies on diet-induced fatty liver.6 This difference between the oxaliplatin group and the irinotecan or control groups was significant (P = .006), but the difference was not significant between the control group and the irinotecan groups. Thus, because http://www.selleck.cn/products/BafilomycinA1.html this oxaliplatin regimen was clinically tolerated the best and was associated most consistently with CASH compared with higher doses of oxaliplatin or different irinotecan regimens, it was chosen as the induction model for CASH to study the effect of FABAC on its occurrence. http://www.selleckchem.com/products/hydroxychloroquine-sulfate.html In total, 42 mice were divided into 3 groups: a control group (n = 6) with no treatment, a chemotherapy group (n = 18) that received the CASH induction regimen (oxaliplatin 6 mg/kg once weekly up to a total dose of 24 mg/kg), and a FABAC group (n = 18) that received both the CASH induction chemotherapy regimen and C20-FABAC at a dose of 150 mg/kg daily administered by gavage. Four mice in the oxaliplatin group and 6 mice in the FABAC group died during the treatment period. The remaining animals (6 in the control group, 14 in the oxaliplatin group, and 12 in the FABAC group) were killed on Day 29. There were no significant differences noted with regard to animal or liver weights between the groups (Fig. 1). Liver fat content was found to be significantly (P