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The aims of this study were to evaluate the relationship between MAC30 expression and clinicopathologic features while investigate the prognostic value of MAC30 expression in breast cancer. Immunohistochemistry was used to examine MAC30 expression in 243 breast cancer tissues, meanwhile in 59 matched adjacent noncancerous tissues and 46 benign breast tumor tissues as controls. The correlation of MAC30 expression with clinicopathological parameters was assessed using ��2 analysis. The Kaplan�CMeier method and Cox proportional hazards model were used to predict factors with a significant independent prognostic value. MAC30 was overexpressed in breast cancer compared with matched adjacent noncancerous tissues and benign breast tumor (both P? http://www.selleckchem.com/products/epz-5676.html MAC30 expression had significantly poorer overall survival (OS) and disease-free http://www.selleck.cn/products/Staurosporine.html survival (DFS; P?=?0.002 and P?=?0.007, respectively). Multivariate Cox regression analysis revealed that high MAC30 expression was an independent prognostic factor for both OS and DFS (P?=?0.018 and P?=?0.044, respectively). Overexpression of MAC30 was associated with tumor progression, recurrence, and poor survival in breast cancer. Testing expression of MAC30 will be helpful for predicting prognosis in breast cancer. J. Surg. Oncol. 2013;107:456�C462. ? 2012 Wiley Periodicals, Inc. ""The optimal margin in breast-conserving surgery is controversial, and re-excision is common. Pathologic margin assessment is not standardized, and tumor biology and the use of systemic therapy have a major impact on local control. A study-level meta-analysis found no difference in local recurrence for margin widths of 1, 2, and 5?mm, leading a multidisciplinary panel to recommend adoption of no ink on tumor as the standard definition of a negative margin. J. Surg. Oncol. 2014 110:2�C7. ? 2014 Wiley Periodicals, Inc. ""The aim of this study was to investigate the expression levels of miR-19a in non-small cell lung cancer (NSCLC) tissue and serum, and to clarify the relationships of serum miR-19a expression with clinical factors and prognosis http://www.selleckchem.com/products/ly2109761.html of NSCLC patients. Expression levels of miR-19a in 25 paired NSCLC, paracancerous tissues and serum, and sera from 103 controls and 201 NSCLC patients were respectively detected using real-time quantitative PCR. Compared with the paracancerous tissue, miR-19a was overexpressed in NSCLC tissue (P?=?0.006), and there was a strong correlation between expression levels of miR-19 in 25 paired sera and tissues (P?=?0.001). Serum miR-19a expression in NSCLC patients was significantly upregulated compared with those in healthy individuals (P?=?0.001). High serum miR-19a expression was significantly correlated with TNM stage and lymph node metastasis (P?=?0.