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6 (18.4) vs. 37.6 (18.0)] and psychomotor speed [?0.46 (1.03) vs. 0.06 (0.80)] at baseline. After controlling for all study covariates (model 2), increasing tHcy concentrations were significantly associated with worse performance in episodic memory, executive functioning and verbal expression, but not global cognition 7?years later: RDs for tHcy as a continuous variable were 0.87 (95% CI 0.76�C0.99) for episodic memory, 0.88 (95% CI 0.78�C0.99) for executive functioning and 0.91 (95% CI 0.83�C1.00) for verbal expression. The relationship between baseline tHcy and episodic memory remained unchanged even after including all three biomarkers into http://www.selleckchem.com/products/midostaurin-pkc412.html the model (model 3). In nondemented subjects, elevated http://www.selleckchem.com/products/liproxstatin-1.html holoTC concentrations were significantly related to better performance in executive functioning [holoTC as a continuous variable: 1.10 (1.00�C1.21)] and psychomotor speed [highest holoTC quartile: 1.22 (1.08�C1.39)], but not global cognition or verbal expression. These estimates changed slightly after controlling for other study covariates (P? https://en.wikipedia.org/wiki/Ketanserin for tHcy and folate attenuated the results, although the direction of associations remained unchanged (data not shown). Compared with the first quartile, the second and third quartiles of baseline folate were significantly associated with higher MMSE scores: RD was 1.12 (95% CI 1.03�C1.21) for the second quartile and 1.09 (95% CI 1.01�C1.18) for the third quartile; whereas the second and fourth quartiles were related to better performance in verbal expression: RD was 1.08 (95% CI 1.01�C1.16) for the second quartile and 1.08 (95% CI 1.01�C1.17) for the fourth quartile, after controlling for baseline study covariates. The association between the second folate quartile and MMSE remained significant even when tHcy and holoTC were incorporated into the models simultaneously: 1.11 (1.03�C1.20). No relationship between folate and cognitive performance was found after excluding subjects with low folate levels. In this prospective population-based study of elderly subjects, higher tHcy concentrations were related to worse cognitive performance 7?years later, irrespective of several potential confounders, including common vascular risk factors. In addition, higher holoTC levels had a protective role for several cognitive domains. The protective effect of holoTC was present over the whole normal range of holoTC concentrations.