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The study followed the tenets of the Declaration of Helsinki and was approved by the ethics committee of the Tel-Aviv Sourasky Medical Center. Twenty consecutive children (12 girls and eight boys) were included in the study group. Eleven of the haemangiomas (55%) were on the right side and 9 (45%) were on the left side. Twelve (60%) haemangiomas were located on the upper eyelid, five on the lower eyelid (25%) and three in the medial cantus (15%). The average age at which the parents became aware of the lesion was 8?weeks (range 1�C24?weeks). The mean age at the time of assessment by US and CDI was 22?weeks (range 5�C44?weeks). The mean follow-up time was 23?months (range 10�C51?months). During the follow-up period, clinically, the tumour resolved completely in 10 children http://www.selleckchem.com/products/Rapamycin.html (50%) and in 10 children (50%) partial resolution was documented. Seven http://www.selleckchem.com/products/MG132.html children (35%) were treated with intralesional corticosteroid injections, systemic corticosteroids or propranolol. Indications for treatment were astigmatism and anisometropia (n?=?4), visual axis occlusion (n?=?2) and cosmetic (n?=?1). Surgery was not indicated in any of the children. The demographic data and the clinical course of the patients are presented in Table?1. Grey-scale US depicted a solid-tissue, well-delineated mass in 15 lesions (75%), while five masses (25%) had indistinguishable borders. The CDI demonstrated numerous blood vessels within the mass and the vessels at the lesion periphery could delineate the borders clearly, thus enabling the measurement of the lesion boundaries. There were no calcifications in any of the masses. Eighteen cases were hypoechoic with internal homogenicity while two cases were heterogeneous containing both hypo- and hyperechoic components. The mean volume of the haemangioma was 1.33?cm3 (range 0.2�C10.6?cm3). The spectral http://www.selleck.cn/products/Bleomycin-sulfate.html tracing demonstrated arterial flow with PSV between 8 and 25?cm/second (mean 15.2?cm/second) and a RI between 0.33 and 0.67. In each lesion, at least three RI measurements from different sites within the lesion were taken. There were only minor differences between the repeated RI measurements in each lesion and a mean RI was calculated for each mass (Table?2). The mean RI for all lesions was 0.51. In 16 patients, RI was