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Median progression-free survival in this population was 2.5?years. A PSM was present at the apex in 56 patients (40%), mid-gland in 17 (12%), base in 30 (22%), bladder neck in 21 (15%), and anterior fibromuscular region in 15 (11%). PSM was found at a single site in 85 cases (73%) and in more than one location in 32 patients (27%) (Table?2). The distribution of PSM location did not differ significantly when stratified by clinical stage. On univariate Cox regression analysis, aggregate PSM length as a continuous variable (HR?=?1.2 for each 1-mm length; P? https://en.wikipedia.org/wiki/Crotamiton and as a categorical variable (HR?=?2.48; P? http://www.selleckchem.com/products/rxdx-106-cep-40783.html a significant predictor for BCR. As a continuous variable (Table?4), PSM length retained its association with increased BCR risk (HR?=?1.14; P?=?0.049). As a categorical variable, aggregate PSM length ��2?mm (HR?=?1.41; P?=?0.32) was not a significant predictor for BCR. Positive lymph node status (HR?=?2.59 and P?=?0.01; HR?=?2.42 and P?=?0.02) and increasing http://www.selleckchem.com/products/CP-673451.html Gleason grade (HR?=?2.2 and P?=?
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