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This may assist the primary care team's ability to successfully use diabetic ulcer prevention strategies. A brief summary of some important clinical studies and ongoing research is presented earlier. The long-term goal of this research is to further the role of thermometry and thermography in clinical care for the diabetic foot, especially by empowering the primary care team to identify high-risk patients and preventing traumatic consequences of this disease through objective parameters. Review of key work published in this area, suggests that thermal imaging provides a useful tool for preventing wounds and assessing wound healing. The wound inflammatory index or TI and Charcot stress test may provide a scoring range for the assessment of wounds and acute CN, respectively, by considering physiological as well as morphological changes to the skin's surface. This additionally helps achieve a comprehensive understanding of the significance of small temperature changes in the wounds and its association with wound chronicity. The use of thermal techniques has largely remained a research tool; however, the availability of quantitative tools may help clinical integration and routine assessments. Further works should be aimed at studying as well as documenting thermal findings in lower extremity wounds in well-designed clinical trials. M Bharara and DG Armstrong are on the Scientific Advisory Board for Medavinci, The Netherlands. J Schoess is the president and the chief executive officer of the Eden Medical Inc., which is the prime recipient of the National Institutes of Health Grant (#1R43DK083782) for developing an infrared thermal scanning system for the lower extremity assessment, especially foot ulcers. ""A high frequency of blue eyes and fair skin are reported in northern European Caucasians with type 1 diabetes (T1D). Also there is an inverse relationship between latitude and T1D incidence. We determined whether iris colour and skin pigmentation are risk factors in a Caucasian population living in two Mediterranean regions located at the same latitude with higher ultraviolet B irradiance, but with different T1D incidence. We studied iris colour in 281 consecutive subjects with T1D and 298 controls. Skin type was evaluated by melanin quantification. In Lazio, blue eyes and fair skin type are significantly more common in T1D subjects than in controls (21 versus 9%, p = 0.002; 50 versus 35%, p