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Girls who had other systemic illnesses, other endocrine and metabolic disorders and chromosome abnormalities, were excluded. Girls with conditions that can affect growth and puberty were also excluded. All girls received thyroid hormone replacement therapy (levothyroxine sodium 60�C100?��g/m2/day) after diagnosis. Dosage was adjusted for weight and thyroid function. Thyroid function tests were performed every 2?weeks if the thyroid function was abnormal. Clinical, hormonal and imaging parameters were recorded in detail after 3?months of therapy. Informed consent was obtained from the girl's parents, and the study was approved by the ethics committee of the Provincial Hospital Affiliated to Shandong University. Height was measured without shoes to the nearest 0.1?cm using a standard stadiometer. Body weight was measured with subjects wearing light clothing to the nearest 0.1?kg using an electronic scale. The degree of adiposity http://www.selleck.cn/products/azd6738.html was expressed as body mass index (BMI) (kg/m2). Standard deviation scores (SDSs) of height and BMI were calculated using reference values in Chinese children [8]. Pubertal stages were assessed by physical examinations, according to the criteria established by Tanner [9]. Breast stages (B1�CB5) were evaluated by inspection and palpation. Pubic hair stages (PH1�CPH5) were evaluated by inspection. Girls without clinical signs of puberty (stages B1 and PH1) were considered as prepubertal. All examinations were performed by trained staff. Fasting blood samples http://www.selleckchem.com/products/VX-765.html were collected and centrifuged to obtain serums, which were then stored at ?70��C. Serum-free triiodothyronine (FT3), FT4, TSH, antithyroid peroxidase antibody (anti-TPO Ab) and antithyroglobulin antibody (anti-Tg Ab) were measured by an automated chemiluminescent immunoassay system (Advia Centaur; Siemens, Munich, Germany). Reference ranges for FT3, FT4, TSH, anti-TPO Ab and anti-Tg Ab were 3.5�C6.5?pmol/L, 11.5�C22.7?pmol/L, 0.35�C5.5?mIU/L, 0�C60?IU/mL and 0�C60?IU/mL, respectively. The sensitivity of each assay was 0.3?pmol/L (FT3), 1.3?pmol/L (FT4), 0.001?mIU/L (TSH), 0.1?IU/mL (anti-TPO Ab) and 10?IU/mL (anti-Tg Ab). The intra-assay and interassay coefficients of variation were http://www.selleckchem.com/products/pf-562271.html 100?��g) Triptorelin (Decapeptyl, Ferring, Switzerland). Serum FSH, LH, prolactin (PRL), estradiol (E2) and testosterone (T) were measured automatically by chemiluminescence using a Roche Cobas E170 immunoassay analyzer (Roche Diagnostics, Mannheim, Germany). Reference ranges for FSH, LH, PRL, E2 and T were 1.0�C4.2?IU/L, 0.02�C0.18?IU/L, 4.79�C23.3?��g/L, 5�C20?ng/L and 0.03�C0.68?��g/L, respectively. The sensitivity of each assay was 0.1?IU/L (FSH), 0.1?IU/L (LH), 0.047?��g/L (PRL), 5?ng/L (E2) and 0.02?��g/L (T). The intra-assay and interassay coefficients of variation were