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We have previously shown (Ceriani et al. ASH 2012) that liver FDG uptake was the best cut-off to predict outcome for patients (pts), providing the first validation of utility for the Deauville criteria in end-of-therapy PET evaluation of PMLBCL. We report here the analysis of the prognostic impact of functional PET parameters at baseline in PMLBCL. The aim of the study was to assess the prognostic value of (i) the metabolic activity as measured by maximum standard uptake value (SUVmax), (ii) the metabolic tumour burden as measured by metabolic tumour volume (MTV) and (iii) total lesion glycolysis (TLG) estimated on 18FDG PET-CT performed at baseline, in pts enrolled in the IELSG-26 trial. http://www.selleck.cn/products/Staurosporine.html Patients and Methods: SUVmax, MTV and TLG were measured following a standard protocol in 103/125 pts (baseline PET was not available in 20 pts having been omitted because of the urgency of treatment, and in two for technical problems). All pts received R-CHOP(-like) or R-MACOP-B(-like) regimens; 93 pts had consolidation radiotherapy to the mediastinum. Cut-offs were calculated for each parameter using the receiver operating characteristic curve. The impact on progression-free (PFS) and overall survival (OS) of the PET functional parameters and of the main clinical features (LDH, stage, B-symptoms, bulk, performance status and international prognostic index) was analyzed. Results: At a median follow-up of 36?months, the PFS and OS rates were 87% and http://www.selleckchem.com/products/ly2109761.html 94%, respectively. By univariate analysis (logrank test), SUVmax, MTV and TLG, as well as bulk >10?cm and stage >2, were significantly associated with worse PFS and OS. In Cox models including SUVmax, MTV, TLG, bulk >10?cm and stage >2, only TLG retained statistical significance for both OS (p?=?0.038) and PFS (p?=?0.002). At 5?years, OS was 100% for pts with low TLG vs 80% for those with high TLG (p?=?0.0001), while http://www.selleckchem.com/products/epz-5676.html PFS was 97% vs 64%, respectively (p?