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Twenty-six of the 38 females were cotreated with six cycles of GnRH agonist triptorelin (Decapeptyl 3.75 mg) for 6 months. No differences in COF were demonstrated between the patients treated with the GnRH agonist and those who did not receive this therapy, which http://www.selleckchem.com/products/VX-770.html may be attributed to the low rate of ovarian failure (6%) in these patients. EB was associated with a significantly higher toxicity compared with SB, which led to a 40% hospitalization rate per cycle versus 8 and 39% grades III and IV neutropenia versus 10%, respectively (P http://www.selleck.cn/products/mi-773-sar405838.html 18��twice; four��thrice, and seven��four times. Hepatic toxicity grades III and IV occurred in three patients following EB. Therapy was reduced to SB in two of them after the first cycle, and it was completely discontinued in the third patient. Grade III cardiac toxicity was diagnosed in three patients following EB, resulting in therapy reduction to SB. An additional patient developed pericarditis after the second cycle of SB. All these individuals recovered from their toxicity before the next cycle of chemotherapy. One patient had small bowel obstruction following the first cycle of SB and refused further chemotherapy. In three patients, aseptic necrosis of the femur head evolved after treatment: in two patients, following 14 days http://www.selleckchem.com/products/Imatinib-Mesylate.html and in one patient following 7 days of steroid therapy taken with each cycle of chemotherapy. Since 2002, duration of prednisone therapy has been reduced to 1 week only. One patient suddenly died at home after four cycles of SB, presumably from a cardiac event. In four patients, a second malignancy was revealed during the follow-up: one breast carcinoma, two non-Hodgkin lymphoma; the fourth patient with primary resistant disease, who underwent high-dose chemotherapy together with stem cells rescue, developed a secondary myelodysplastic syndrome that could be related either to primary or salvage therapy. HL treatment has remarkably developed over the past two decades. Standard therapeutic regimens provide a 5-year event free survival (EFS) of 72�C81% for patients with a low IPS (��2) and of 64�C69% for individuals with a higher IPS [11]. Diehl et al. [8] reported that intensive therapy, such as eight cycles of EB, is more effective in terms of freedom from treatment failure; however, this was achieved at the cost of multiple episodes of febrile neutropenia, increased risk for secondary leukemia and early menopause for women in their fertility age [3, 5, 8]. Such toxicity served as rationale for further studies investigating indications for dose reduction. Similar outcomes were demonstrated in patients receiving eight cycles of EB and four cycles of EB + four cycles of SB [2, 12]. These results suggest that only a small subpopulation of patients require a full EB course.