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ECC grip training may provide a greater skeletal benefit in the distal radius, but a larger and longer study of these training adaptations is necessary. These results are important for optimizing the design of exercise interventions aimed at increasing bone strength at the clinically relevant distal radius. Disclosures: Andrew Frank, None. MO0055 Effects of Prolonged Unloading on the 3D Microarchitecture of Rat Cortical Bone.Hayley Britz*1, Jarkko Jokihaara2, Olli Leppanen3, Teppo Jarvinen4, David Cooper1. 1 University of Saskatchewan, Canada, 2 University of Tampere, Canada, 3 University of Tampere, Finland, 4 University of Tampere/IMT, Finland Bone is capable of adapting to changes in loading; however little is known regarding how loading affects the internal 3D microarchitecture of cortical bone. This is due to the heavy focus which is put on studying the effects of loading http://www.selleckchem.com/products/a-1155463.html on trabecular bone and the gross surface changes (modeling) of cortical bone. The aim of this study was to experimentally test the hypothesis that loading is a determinant of the 3D orientation of vascular canals. This objective was addressed by observing how the primary cortical microarchitecture (canal network) of rat tibiae was affected by unloading during growth. The left tibial diaphysis from ten rats (30 weeks old) that had been immobilized by sciatic neurectomy for 27 weeks and the left tibial diaphyses from ten control rats (30 weeks old) were scanned in a micro-CT. Our lab has previously found that desktop micro-CT, operating at 3 micron nominal http://www.selleckchem.com/products/cb-5083.html resolution, is an effective means of visualizing and quantifying rat cortical bone porosity. Canal volume fraction, mean canal diameter, mean canal spacing and mean canal orientation were quantitatively assessed. Qualitative observations of the canal networks in 3D revealed a marked regional variation within the tibial cross section. Both groups exhibited large numbers of radial canals with these were more predominate in the unloaded specimens. Quantitatively no differences were found between immobilized and control rats for canal volume fraction and canal separation (p=0.177 http://www.selleck.cn/products/PD-0332991.html and p=0.146, respectively). Canal diameter was significantly greater in immobilized rats as compared to control rats (p