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3% with single positivity to BV had sIgE to Api m 1. None of the 45 patients with single positivity had sIgE to rSSMA of the other species, while one nonatopic control had low sIgE of 0.42?kUa/l to Ves v 1, but not to Ves v 5. In patients with single positivity to VV, sensitivity http://www.selleckchem.com/products/3-methyladenine.html of Ves v 5 was optimal, while only 33.3% had also sIgE to Ves v 1. In patients with double positivity to BV and VV, the majority had sIgE to Ves v 5 (76.3%) and also to Ves v 1 (59.2%). Eight patients had only sIgE to Ves v 1 and 21 only to Ves v 5. Table?3 compares sIgE to whole venoms and to rSSMA in relation to the culprit insect according to the history. Double positivity of rSSMA was present in nine of 10 (90%) patients with a history of systemic reactions to both insects. One patient of this group was single positive to rSSMA of VV. He had developed a grade 4 reaction following a Vespula sting 3?months before testing and a mild grade I reaction to a bee sting 3?years before. sIgE http://www.selleck.cn/products/Cisplatin.html to BV were of class 3, and sIgE to VV were of class 2. Of 25 patients who were unable to identify the culprit insect, 18 (72%) were double positive to rSSMA. Of the 22 patients with a history of a Vespula as culprit insect, none was double positive to rSSMA, although five of 11 with available data remembered previous well-tolerated bee stings. One patient had no sIgE to rSSMA of either venom, while sIgE to both whole venoms were of class 2. The sting of the culprit insect had occurred 3?months before testing. Of the 19 patients with a history of a bee as the culprit insect, 18 were positive to BV rSSMA, but nine also to VV rSSMA. http://www.selleckchem.com/products/PD-0325901.html Of nine patients with available data and double positivity of sIgE to rSSMA, eight remembered previous well-tolerated wasp stings. One patient, a 7-year-old boy, son of a beekeeper, had developed several mild SAR to bee stings, the last 9?months before testing. He had well-tolerated several Vespula stings before. Surprisingly, sIgE were positive only to VV rSSMA, while sIgE to whole venoms were of class 2 for both species. As shown in Table?2, sIgE to CCDs were present in 54% of patients with double positivity but only 2.2% of those with single positivity (��2?=?35.623, P?