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02; 92 and 71% increases from baseline conditions). No apparent differences in prolonged EMG responses were observed between individual knee extensor muscles. In control subjects, during low-amplitude (22.3 �� 10.3 mA) variable-frequency NMES, low levels of augmented torques were evident during the second versus first 25 Hz stimulation during baseline (pre-MVE) testing (21 �� 9% increase), with non-significant decrease following single or repeated MVEs (P= 0.93; 6% decrease following three contractions versus resting conditions). Torque and EMG activity http://en.wikipedia.org/wiki/MERTK following stimulation followed a similar trend, with relatively low baseline values (0.47 �� 0.20 N m and 4.9 �� 0.90 mV ms respectively). Non-significant changes in prolonged torque and EMG were also observed following single or repeated contractions (P= 0.82 and P= 0.71 respectively). This represents a 49% decrease in prolonged torque and 9% increase in prolonged EMG following three contractions versus resting conditions in healthy controls. Unpaired comparisons between responses to variable-frequency NMES in SCI and control subjects at each of the four preceding conditions (0, 1, 3 and 5 contractions) were not significant (P values range from 0.06 to 0.48). Greater augmented and prolonged torques during low-amplitude variable-frequency NMES following three and five MVEs in individuals with SCI mirrors the increases in peak knee extensor torques with repeated MVEs in the present and previous investigations (Hornby et al. 2009). Correlation analyses were performed to examine potential associations between http://www.selleckchem.com/products/SRT1720.html peak http://www.selleckchem.com/products/Adrucil(Fluorouracil).html torque increases during the bout of one, three or five MVEs (normalized to peak baseline values) and EMG/torque parameters determined with variable-frequency NMES. Across all trials (n= 51), there were low to moderate, but significant, correlations between peak torque during the repeated one to five MVEs and augmented torques during the second 25 Hz (r= 0.31, P= 0.02), prolonged torques post-stimulation (r= 0.57, P