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Patients in the ��75% M protein reduction group had the highest CR + PR rates of 97.9% and 95.0% in the PLD + bortezomib and bortezomib alone treatment groups, respectively. The safety profiles of the 2 treatment groups, PLD + bortezomib http://www.selleckchem.com/products/z-vad-fmk.html and bortezomib alone, were comparable at the cycle 2 landmark (Table 3). Of the 404 patients evaluated at the cycle 2 landmark, 17% of patients receiving PLD + bortezomib experienced a ��grade 3 adverse event, compared with 13% of patients receiving bortezomib alone. As expected, patients receiving PLD + bortezomib experienced more hand-foot syndrome compared with patients receiving bortezomib alone and more mucositis/stomatitis, but less peripheral neuropathy both overall, and at the grade 3 and 4 levels of severity. Overall safety profiles in this analysis were similar to the overall safety profiles for the previously reported phase 3 study.4 Analyses of modern therapeutic approaches to multiple myeloma with regimens incorporating novel agents have generally supported the hypothesis that response quality predicts long-term outcomes, with deeper responses being associated with longer TTP and overall survival.2 However, there is some controversy about whether the early response rapidity is similarly predictive. Schaar and colleagues conducted a study that prospectively evaluated the relationship between survival and the rate of M protein decrement during the first cycles of therapy in 262 http://www.selleckchem.com/products/ly2157299.html patients with newly diagnosed multiple myeloma who were included in a phase 3 trial (HOVON-16).7 In this study, the median M protein decrease after the first cycle of MP was 21% for IgG and 27% for IgA, and declined http://www.selleck.cn/products/XL184.html to