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Not unexpectedly, men who with a at high baseline fracture risk and who received ADT within 1 year of cancer diagnosis had a higher incidence rate of fractures compared to other groups. During the 12-year follow-up, more than 58% of men in the high-risk group and 38% of men in the low-risk group developed a fracture, whereas 31% of men in the low-risk group that did not receive ADT sustained a fracture. The incidence of fracture was estimated as the event rate per 1000 among the groups that did or did not receive ADT, and did or did not have attempted curative treatment, as well as the risk to fracture at baseline (Table?2) ADT was divided into those who underwent orchidectomy and those who received GnRH agonist treatment according to the number of doses received (1�C5, 6�C17 or ��18). An increasing number http://www.selleckchem.com/products/loxo-101.html of ADT doses was associated with a marked increase in the risk of fracture in http://www.selleck.cn/products/ON-01910.html all men. The absolute increases in fracture rate were particularly high among men who had ADT as their only treatment and had a high fracture risk at baseline. In the group who received ADT as their only treatment, the fracture rate increased by 32.9 per 1000 (from 52.9 to 85.8) for men who did not receive ADT compared to those who underwent orchidectomy in the high-risk group vs 28.5 per 1000 (from 28.9 to 57.4) in the low-risk group. In the group who had ADT along with RT or RP, the fracture rate increased by 14.8 per 1000 (from http://www.selleckchem.com/products/abc294640.html 45.2 to 60.0) for men who did not receive ADT compared to those who underwent orchidectomy in the high-risk group vs 15.8 per 1000 (from 25.9 to 41.7) in the low-risk group. The risk of fracture associated with an increasing ADT dose adjusted for other covariates is presented in Table?3. The HR of the occurrence of a fracture increased with the cumulative number of doses of a GnRH agonist received after prostate cancer diagnosis. After adjusting for the effect of other variables, the effect of ADT dose on fracture risk was stronger in men who had ADT as their only treatment compared to those who received ADT with other attempted curative treatments. Among men who received ADT only, the fracture risk (HR) of men receiving ��18 doses of GnRH agonist was 1.53 (95% CI, 1.44�C1.62) for the low-risk group and 1.27 (95% CI, 1.20�C1.35) for the high-risk group compared to men who did not receive ADT. Among men who received ADT and other curative treatments, the fracture risk was 1.37 (95% CI, 1.27�C1.49) for the low-risk group and 1.20 (95% CI, 1.09�C1.33) for the high-risk group. Fracture is associated with an increase in overall mortality. The mortality among men experiencing a fracture was 6.27% within 6 months and 9.87% within 12 months. Figure?2 presents the survival probability by fracture.