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However, patients with end-stage kidney disease without heart involvement had higher concentrations of BNP and NT-proBNP than subjects with preserved eGFR (P http://www.selleckchem.com/products/smoothened-agonist-sag-hcl.html failure without heart involvement and patients with heart involvement with preserved eGFR or moderate to severe renal failure. Six ROC curves were plotted to evaluate the discrimination ability of BNP and NT-proBNP to identify patients with amyloid http://www.selleckchem.com/products/epz015666.html cardiac involvement as assessed by echocardiography (Fig. 2). Both natriuretic peptides proved good markers of heart involvement in the three groups. The area under the curve of NT-proBNP and BNP was lower, though not significantly, in patients with end-stage renal failure than in the other groups. Natriuretic peptide Type B was not superior to NT-proBNP in identifying cardiac involvement in patients with renal failure. However, a higher NT-proBNP cutoff was required for the detection of heart involvement in patients with moderate to severe renal failure (543 ng L?1) and in those with end-stage renal disease (2,642 ng L?1) compared to patients with preserved eGFR (332 ng L?1). Conversely, the BNP cutoffs were almost identical in Group 1 (73 ng L?1) and Group 2 (78 ng L?1), whereas it was approximately three times higher in patients with end-stage renal insufficiency (221 ng L?1). Thus, we repeated the ROC analysis for BNP merging Groups 1 and 2: the area under the ROC curve was 0.94 (95% CI: 0.89�C0.97) and the cutoff was 73 ng L?1, showing a 89% sensitivity (95% CI: 82�C94%) and http://www.selleck.cn/products/SP600125.html a 85% specificity (95% CI: 75�C93%). Moreover, we repeated the ROC analyses in Groups 1 and 2 excluding previously treated patients. This was not possible in Group 3 due to the small number (9) of untreated subjects. The NT-proBNP and BNP cutoffs identified in untreated patients were almost identical with those of the overall population: in Group 1, 73 ng L?1 for BNP and 332 ng L?1 for NT-proBNP, and in Group 2, 78 ng L?1 for BNP and 540 ng L?1 for NT-proBNP. The results of the analyses did not change if the nine patients who were not undergoing dialysis were excluded from Group 3.