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Hormone levels and body mass index/waist circumference were correlated with patient- and tumor-specific characteristics using multivariable logistic regression analysis. Even though we confirmed an inverse correlation between bodyweight and testosterone levels, only overweight �C but not low testosterone �C was associated with advanced disease and poor differentiation of prostate cancer. Using multivariate analyses, both body mass index ��30?kg/m2 and waist circumference >110?cm were associated with high-grade disease (Gleason score ��8). A waist circumference >110?cm also correlated significantly with lymph node metastasis. This is the first study showing that obesity, but not low serum testosterone levels, is significantly http://www.selleckchem.com/products/rxdx-106-cep-40783.html associated with high grade and metastatic disease in men diagnosed with clinically localized prostate cancer. The present findings suggest that low androgen levels at diagnosis, which used to be held responsible for the development of aggressive prostate cancer, is only an epiphenomenon of obesity rather than the cause of prostate cancer development and/or progression. ""To describe the prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy for bladder malignancy; to quantify the association between incidental prostate cancer https://en.wikipedia.org/wiki/Crotamiton and mortality in these patients; and to quantify the association between incidental prostate cancer and age http://www.selleckchem.com/products/CP-673451.html in radical cystoprostatectomy specimens. Consecutive patients undergoing radical cystoprostatectomy for bladder malignancy at six academic institutions were assessed. End-points were the histological diagnosis of prostate cancer in the radical cystoprostatectomy specimens and mortality. The association between incidental prostate cancer and mortality was calculated by multivariable Cox regression, and the association between age and the occurrence of prostate cancer was calculated by logistic regression. A total of 1122 patients (aged 65.6?��?10?years) were included in this analysis. Prostate cancer was detected in 17.8% (n?=?200) of the cystoprostatectomy specimens. After multivariable adjustment, prostate cancer was significantly associated with mortality (hazard ratio 1.27, 95% confidence interval 1.03�C1.56). There was a significant association between age and the presence of prostate cancer in the cystoprostatectomy specimen. The odds ratio for the presence of prostate cancer was 1.028 (95% confidence interval 1.011�C1.045; P?